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Mike Lauer is on the right track. I think considering citations per publication per grant, or citations per grant is another good idea; those will force a PI do research that will make the most impact in the field, to move the research forward instead of sideways. Too many are churning out fluff just to make the numbers come grant renewal time. Another good idea I saw in the responses is to integrate citations in the patent databases in the impact factor determination. If the PI’s research was of substance, the publication will be used by pharma (this also will show the research was reproducible) and will be cited in their patent applications. I’d stress again that NIH needs to require PI’s to list the overall citation impact factor of their publications in their NIH biosketch. Too many tax payer dollars are being wasted on non-reproducible research and on research that will never have any practical value. Joe Biden’s Moonshot will come to nought if the current status quo continues without serious changes.